Tox Round Table (TRT) is a professional learning community for toxicology practitioners, established in October 2023 to help bridge this gap. It combines ongoing online discussions with regular in-person workshops. Each week, a designated moderator proposes a topic, and members freely ask questions, share perspectives, and exchange practical knowledge.

The community follows three principles. First, there is no participation fee. Second, company confidential information is strictly excluded, and discussions are limited to practical toxicology matters. Third, the quality of a question—not a participant’s title or affiliation—determines their voice in the discussion. I have witnessed many occasions when a question from a newly appointed practitioner proved more valuable than an answer from someone with 20 years of experience.

Over the past three years, more than 230 professionals from pharmaceutical and biotechnology companies, CROs, hospitals, universities, and regulatory authorities have participated, generating more than 3,500 questions. Topics have ranged from follow-up strategies for Ames-positive drug candidates and ADA-related changes in TK exposure to digital pathology, AI-based toxicity prediction, and genotoxicity assessment of mRNA vaccines. The range of subjects discussed provides a meaningful record of the challenges our industry has faced in recent years.

TRT is not a program operated by a particular institution. It is an open community built collectively by its participants. My role is simply to facilitate the process; the discussion always centers on the professionals who must make real-world decisions in the field. I will continue to support this community and help it grow.

We warmly welcome the participation of anyone interested.